GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6988636 | 1 | rs62521841 | chr8:124194625 | FAM83A | chr8:124191287-124222317:+ | -0.33 | -4.06 | 5.83E-5 | Urinary uromodulin levels |
| THCA | cis | rs670523 | 1 | rs625658 | chr1:155891045 | FDPS | chr1:155278539-155290457:+ | -0.21 | -4.43 | 1.15E-5 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs670523 | 1 | rs625658 | chr1:155891045 | RIT1 | chr1:155867601-155881177:- | 0.17 | 3.83 | 0.000143 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs7866350 | 1 | rs62574275 | chr9:100985311 | TBC1D2 | chr9:100961281-101018003:- | 0.28 | 7.01 | 8.42E-12 | Post-traumatic stress disorder |
| THCA | cis | rs7866350 | 1 | rs62574275 | chr9:100985311 | TSTD2 | chr9:100362364-100395962:- | 0.16 | 3.56 | 0.000415 | Post-traumatic stress disorder |
| THCA | cis | rs6671200 | 1 | rs62625008 | chr1:95702582 | RWDD3 | chr1:95583479-95712773:+ | 0.27 | 3.54 | 0.000432 | Stearic acid (18:0) plasma levels |
| THCA | cis | rs589756 | 1 | rs627460 | chr6:132640030 | MOXD1 | chr6:132617195-132722664:- | 0.25 | 4.41 | 1.27E-5 | Obesity-related traits |
| THCA | cis | rs6494537 | 1 | rs627804 | chr15:65734040 | DPP8 | chr15:65737999-65810035:- | -0.09 | -3.78 | 0.000176 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs627804 | chr15:65734040 | SLC24A1 | chr15:65903704-65953256:+ | -0.15 | -3.75 | 0.000195 | Mean corpuscular hemoglobin |
| THCA | cis | rs35123781 | 1 | rs627817 | chr5:139054506 | DNAJC18 | chr5:138747381-138775139:- | 0.17 | 3.81 | 0.000158 | Schizophrenia |
| THCA | cis | rs7528419 | 1 | rs629301 | chr1:109818306 | SYPL2 | chr1:110009100-110024763:+ | 0.15 | 3.39 | 0.000767 | Cholesterol, total;Myocardial infarction;Coronary artery disease;Lipoprotein-associated phospholipase A2 activity and mass |
| THCA | cis | rs2639990 | 1 | rs632157 | chr18:72911548 | ZADH2 | chr18:72909279-72921281:- | 0.29 | 4.67 | 3.86E-6 | Vascular endothelial growth factor levels |
| THCA | cis | rs7474896 | 1 | rs633400 | chr10:38329421 | LOC399744 | chr10:38717074-38741080:+ | 0.28 | 3.85 | 0.000133 | Obesity (extreme) |
| THCA | cis | rs7474896 | 1 | rs633400 | chr10:38329421 | ZNF25 | chr10:38238795-38265453:- | 0.16 | 3.46 | 0.000596 | Obesity (extreme) |
| THCA | cis | rs1171113 | 1 | rs633554 | chr6:84265708 | SNAP91 | chr6:84262607-84419127:- | -0.19 | -3.71 | 0.00023 | Bipolar disorder with mood-incongruent psychosis |